CONTRIBUTOR(S): Emma Chandley, Linda Horspool,

Medication: Phenylpropanolamine
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Your cat has been prescribed phenylpropanolamine for the treatment of urinary incontinence. This medication works by strengthening the muscles around the urethra, helping to prevent accidental urine leakage.
Key points:
- Phenylpropanolamine can be used in cats to manage urinary incontinence.
- Currently, there are no licensed veterinary products available for cats containing phenylpropanolamine. Its use in cats is described as ‘off label’ because it is not licensed for use in cats. Your veterinarian will be able to explain the regulations relating to prescribing drugs off label for your cat.
- The drug works by strengthening the muscles around the urethra to reduce urine leakage.
- It is very important to follow your veterinarian’s dosing instructions carefully as cats can be sensitive to certain medications.
- Close monitoring is necessary to ensure safe and effective use.
- Phenylpropanolamine
- Proin, Propalin
- Sympathomimetic agent
- Store at room temperature, protected from moisture and direct sunlight. Keep out of reach of children and pets.
Why has my cat been prescribed phenylpropanolamine?
Your veterinarian has prescribed phenylpropanolamine for the treatment of urinary incontinence in your cat. It works by strengthening the muscles around the urethra, which helps to control urine leakage.
How is the medication given?
Phenylpropanolamine is usually administered orally, either as a tablet or liquid. The medication is typically given once or twice daily based on your veterinarian’s guidance. Make sure to give the dose exactly as prescribed.
Are there any side effects or drug interactions?
The following side-effects have been reported:
- Increased heart rate or blood pressure.
- Restlessness or mild agitation.
- Decreased appetite.
- Vomiting or diarrhea (less common).
- Rarely, increased anxiety or behavioral changes in sensitive cats.
Drug interactions can occur with:
- Certain antidepressants (eg monoamine oxidase inhibitors (MAOIs)).
- Certain antidepressants.
- Blood pressure medications.
How long will my cat need to receive this medication?
Phenylpropanolamine should be administered according to your veterinarian’s instructions. Your cat may need to stay on phenylpropanolamine long-term. Your veterinarian will determine the appropriate treatment duration based on how well your cat responds to the treatment. Phenylpropanolamine should not be stopped suddenly. Your veterinarian will help you decide the best plan for your cat.
How should I dispose of this medication if I don’t use it all?
Dispose of any unused phenylpropanolamine following your veterinarian’s guidance or local regulations in a safe manner. Avoid throwing it away or flushing it down the toilet, as it could harm pets or wildlife if accessed. Check with your veterinary team to see if they take back medication for disposal. Don’t save any remaining phenylpropanolamine to use at a later date or to give to any other animals.
What if I miss a dose or give an extra dose?
If you miss a dose, give it as soon as you remember unless it’s almost time for the next dose. Never give double doses. If an extra dose is given by mistake or you accidentally overdose your cat, contact your veterinarian immediately as too high a dose could lead to adverse effects.
My cat is unwell, should I still give the drug?
If your cat is unwell, it’s best to consult your veterinarian before administering phenylpropanolamine. Certain illnesses may require the dose to be adjusted or treatment to be stopped.
What should I do if this medication is accidentally taken by a human?
Phenylpropanolamine should only be given to the cat that it has been prescribed for. If a person accidentally ingests the medication, seek immediate medical advice, as it can affect heart rate and blood pressure.
Will my cat need to be monitored while on phenylpropanolamine?
Yes, your cat may need periodic veterinary check-ups, particularly to monitor blood pressure, behavior and urinary health, as well as other laboratory tests to ensure that the medication’s safety and effectiveness.